Mack Salmon created Muskie to aid him in his newest diabolical scheme. He prowled the swamps of Bohunk Lagoon abducting the population and removing their brains to be used as Salmon's zombie workforce. After Sam and Max shut down Mack's operation, Muskie was given a second chance at a promising career as a live stage performer for Bohunk Lagoon.
Despite his beastly appearance, Muskie was actually an innocent pawned duped into serving Mack Salmon. He seems happier with his new life, but has an extreme hatred for flash photography.