–When defeated by Sam.
Auntie Biotic makes a brief appearance in Reality 2.0.
With her +1 armor and her frying pan she protects Reality 2.0's mail system from being tampered with. Sam & Max eventually defeat her using a +2 Sword and a bunch of pop-ups. Auntie Biotic looks and sounds exactly like Myra Stump.
Auntie Biotic is voiced buy Dorothy Gallagher.
- Her name is a pun of "antibiotic".